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Everything You Need to Know Before You Start Semaglutide

Weight Loss

What is Semaglutide?

Semaglutide is a medication used to treat diabetes and obesity. It works by helping the body process insulin more easily, which in turn lowers blood sugar levels. This can help you feel full for longer periods. Semaglutide also helps retrain your brain to not feel compelled to clear your plate. The medication is injected into the subcutaneous tissue once a week and can be done at home with minimal discomfort.

What Does Semaglutide Feel Like?

Semaglutide has three main mechanisms of action. Slowing gastric emptying, increases insulin sensitivity and reduces compulsions. Semaglutide slows down the speed at which your stomach moves, making you feel fuller longer. This also can create nausea and constipation for some patients. Patients often need to change their diet on semaglutide. Smaller meals and not eating as fast can help patients lose weight on the medication. Shakes and smoothies also tend to be a favorite of patients on semaglutide.

The second mechanism involves increased beta cell production. These cells are responsible for insulin in our bodies. This means your body becomes more efficient at processing blood sugar by increasing insulin sensitivity. Semnaglutide reduces the urge for patients to clear their plates. Dr Jacob Weinstein DNP ACNP, or Dr Jake as his patients call him, referred to this as “leaving the clean plate club. Our parents, aunts, uncles and grandparents taught us to clear our plates growing up. It was a badge of honor to be in the clean plate club; however, it is an unhealthy habit and directly relates to obesity.” Patients who are on semaglutide for six or more months feel less compelled to eat everything on their plate, even after stopping the medication.

What Are Common Semaglutide Side Effects?

Semaglutide can cause side effects, such as nausea, constipation, tiredness, headaches, and fatigue. These can be managed with over-the-counter medication and sometimes prescription medications for nausea. It is important to be in touch with your provider regularly about any side effects your experience as it may be a sign of other medical issues. Nausea can be managed with medication like zofran, which dissolves under your tongue, and constipation is often treated with laxatives for relief.

How Do You Inject Semaglutide?

Semaglutide is a subcutaneous injection. If you use compounded semaglutide from a vial, follow the step below for injecting. Patients should be aware that the concentration of compounded semaglutide differs from one pharmacy to the next. Check with your local or telehealth provider about your dosing schedule.

  • The medication must be kept in the fridge
  • Never inject more than once a week
  • Take Zofran and or Tums every 6 hours as needed for nausea
  • Fast for 12-14 hours before injecting, and eat lightly the day before
  • Avoid dairy the day before and the first few days after you inject
  • Take a stool softener the day before if your bowels move slow
  • Wipe the vial top with an alcohol pad, pull back the plunger to fill the syringe with air
  • Turn the vial upside down, insert the needle and push the air into the vial
  • Withdraw the desired dose – Place the vial back in the fridge!!
  • Turn the vial right side up, so the needle is no longer in the liquid, and remove
  • Exchange the needle for a new one. Warm up your meds! (room temp)
  • Use your thumb and index finger and pinch the skin on your abdomen. Lift the skin away from your body. Wipe the area with an alcohol pad and remove the needle cap
  • Poke the needle straight into the skin you are pinching at a 90-degree angle
  • While keeping the skin pinched, slowly push the plunger on the syringe to push the medication into your subcutaneous tissue
  • Once all medication goes in, you can stop pinching the skin and remove the needle
  • Place the needle into the puncture-resistant container.
Semaglutide Injection

How To Start Semaglutide

Weight Management

Compounded semaglutide is available through telehealth or with your local provider. Patients interested in compounded semaglutide should contact their primary care provider or a weight loss specialist. The pricing varies; generally, compounded semaglutide will cost patients $200-$400 per month. This is dependent on the amount of medication they use each week. Patients should note that their dose of semaglutide will increase over several weeks or months.

If you are starting compounded semaglutide in powder form, check that you will receive bacteriostatic water. You will need this to mix with the powder before injecting the medicine.


If you are interested in starting compounded semaglutide, check with a local provider. Mobile Care Health offers compounded semaglutide delivered to you, teaches you how to inject, and providers who understand the medication. Get started today by texting “semaglutide” to 7193565410

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Clayton Evans

Clayton Evans is an IFA Certified Personal Trainer and IFA Certified Sports Nutritionist with over 5 years of experience in the health and fitness Industry. After years of struggling with his own health and fitness, Clayton lost over 30 lbs and started a career helping others achieve the best version of themselves. Clayton spent several years working with large corporate gyms developing fitness programs and working with Nutrition and Wellness Companies to improve a client’s overall health. His approach with clients is simple – small changes in fitness and diet that will have the largest impact and will fit into a client’s busy lifestyle.

Chad Antonson

Chad is a native of Colorado, growing up on the western slope. He moved to the Denver area in 2019 after working as a wild land firefighter through Job Corps. In his free time he enjoys hiking, skiing and traveling.

Brooke Young

Brooke is a skilled and compassionate Adult Nurse Practitioner with over 10 years of experience in healthcare and a passion for helping patients achieve optimal health and wellness. Brooke holds a Master of Science in Nursing with a specialization in adult health and gerontology from Maryville University of St. Louis. She completed post-graduate training in functional medicine through the Institute for Functional Medicine and obtained her NP board certification through the American Academy of Nurse Practitioners Credentialing Board in 2019. As a Nurse Practitioner, Brooke seeks to address the root causes of disease and treat the whole person, rather than just the symptoms. She believes in taking a personalized and holistic approach to each patient. She has special interests in helping patients heal from metabolic syndrome, achieve their weight loss goals, optimize fertility, and recover from complex chronic illness. In her free time, Brooke enjoys hiking, reading, rollerblading, cooking healthy meals, and spending time with her fun-loving husband and spirited toddlers. She is excited to partner with you on your health journey and support you in achieving your goals.

Kyle Christensen

Kyle is a career Firefighter/Paramedic with extensive experience in the Denver metro area. He holds a bachelors of Health and Exercise Science from CSU. Kyle enjoys weightlifting, skiing, boating, and all the outdoor activities Colorado has to offer.

Jacqueline Carbone

Jacqueline Carbone is a highly experienced nurse practitioner that specializes in providing her clients with holistic, evidenced based, compassionate care. She specializes in Mental health, ketamine assisted therapy and Migraines. She is board certified from the American Nurses Credentialing Center. Jacque has her post Masters certificate from University of Colorado in Psychiatric Mental Health and two master’s degrees—one in acute care/geriatric nursing and one as a clinical specialist in geriatrics—from Georgetown University. She has also completed a fellowship with Dr Arnaldo DeSilva a headache specialist. She is passionate about providing a holistic treatment plan for her clients.

Steve Ohl

Steve is a native of Colorado with bachelors in culinary nutrition. He worked as a classically trained chef, for over a decade. After chef life he shifted careers to join Mobile Care Health as our Operations Manager. Steve enjoys Crossfit, boating, road trips and camping.

Dr. Michael McGurren

Dr Michael McGurren was born and raised in Denver, Colorado. He graduated from Creighton University Medical School, and was the Chief Resident followed at Barnes-Jewish in St. Louis. He is board certified in Emergency Medicine and provides medical direction, as well as urgent care services for Mobile Care Health. In his free time he can be found sailing around the world, with a captains license and over 2500 nautical miles sailed. On shore he enjoys traveling with wife and pup Kylo in custom campervan.